Algorithm Update for Bipolar Depression

The Psychopharmacology Algorithm Project at the Harvard South Shore Program provided a 2020 update on their algorithms for bipolar depression. For the update, researchers reviewed current studies and review articles through PubMed to note which modifications in the recommendations were justified. The first-line treatment option for those who need urgent therapy remains electroconvulsive therapy. The 5 treatments that are recommended for early use in acute bipolar depression alone or in combination when monotherapy fails are lamotrigine, lurasidone, lithium, quetiapine, and cariprazine, with the order to be decided by side effect susceptibility and patient preference. The updated algorithm organizes systematic evidence of critical new studies and the latest treatments approved by the Food and Drug Administration.

Reference:

Wang D, Osser DN. The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An update on bipolar depression. Bipolar Disord. 2020;22(5):472-489. doi:10.1111/bdi.12860

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