Bipolar Disorder and Neurodevelopmental Pathways

In a narrative review, researchers sought to recap findings linked to developmental and perinatal features in addition to epidemiological, clinical, neuropsychological, brain imaging, postmortem brain, and genomic studies that support the recognized etiology and neurodevelopmental pathogenesis of bipolar disorder. Compared with bipolar disorder, aberrations in neurodevelopmental pathways have been more regularly associated with the pathophysiology of schizophrenia; however growing evidence signifies that neurodevelopmental pathways may be linked to the underlying pathophysiology of no less than a subset of those with bipolar disorder. This may be predominantly in those who have an early age of onset and those who experience psychotic symptoms. The investigators of this review propose a heuristic neurodevelopmental model regarding the pathophysiology of bipolar disorder based on their findings, as well as future directions.

Reference: Kloiber S, Rosenblat JD, Husain MI, et al. Neurodevelopmental pathways in bipolar disorder. Neurosci Biobehav Rev. 2020;112:213-226. doi:10.1016/j.neubiorev.2020.02.005

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