Clinical Findings and Pathogenesis of Bipolar Disorder

A graphic from The Calgary Guide to Understanding Disease breaks down the pathogenesis and clinical findings of bipolar disorder. The diagram begins with a description of different genetics, neurotransmitter imbalances, abnormal neurocircuitry, and environmental factors. Bipolar disorder then goes down into the oscillation amongst mood states with depressive episodes, manic episodes, and euthymic mood. If left untreated, those with bipolar I disorder can have approximately 10 episodes of mania and depression per lifetime.

Reference: Bipolar Disorder: Pathogenesis and Clinical Findings. The Calgary Guide to Understanding Disease. Published October 21, 2013. Accessed July 1, 2022.

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