Insight Into the Neurobiology of Bipolar Disorder

In a chapter from the book, Bipolar Disorder, authors give an overview of developing and current neurobiological frameworks in bipolar disorder (BD). Emerging data is making it more clear that the mechanism of disease in BD go further than the brain, offering possible gaps in psychopathology and increased medical comorbidities. This is shown by the role of the circadian system in BD increasing, as well as the growing evidence on the influence of spinal afferents to the concept of mood, indicating that brain and body communication pathways are important to BD pathophysiology.

Reference: Romo-Nava, Francisco, and Susan L. McElroy, ‘Neurobiology of Bipolar Disorder: Neurotransmitter and Other Models’, in Stephen M. Strakowski and others (eds), Bipolar Disorder, Primer On Series (New York, 2020; online edn, Oxford Academic, 1 May 2020), doi:10.1093/med/9780190908096.003.0010

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