Reviewing the Neurobiology of Bipolar Disorder

Bipolar disorder (BD) is commonly associated with functional impairment, and while effective pharmacological and non-pharmacological therapies exist, some patients remain symptomatic. Gaining knowledge about the neurobiology of BD may aid in the advancements of future therapeutic targets in addition to certain biomarkers for early detection, prognosis, and treatment response. In a review, researchers examine molecular, genetic, epigenetic, physiological, and neuroimaging findings that relate to BD and its neurobiology.

Reference: Scaini G, Valvassori SS, Diaz AP, et al. Neurobiology of bipolar disorders: a review of genetic components, signaling pathways, biochemical changes, and neuroimaging findings. Braz J Psychiatry. 2020;42(5):536-551. doi:10.1590/1516-4446-2019-0732

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