Unipolar and Bipolar Clinical Progression
Investigators conducted a systematic review of extensive literature from Medline, Embase, and PsychInfo combined with cross-references to show evidence of the associated with the amount of affective episodes and risk of episode recurrence, likelihood of recovery from episodes, episode severity, threshold for episode development, and the development of cognitive deficits in both unipolar and bipolar disorders. Studies that had the longest follow-up times with survival analysis methods showed to support clinical progressive illness course. It was found that the rising amount of affective episodes appeared to be linked to occurrences including higher risk of recurrence, episode duration, and severity of symptomatic episodes, as well as a decreased threshold for the development of episodes. Investigators concluded that while the course of illness is heterogeneous, evidence shows clinical progression of both unipolar and bipolar disorders.
Reference: Kessing LV, Andersen PK. Evidence for clinical progression of unipolar and bipolar disorders. Acta Psychiatr Scand. 2017;135(1):51-64. doi:10.1111/acps.12667